Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 4/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5485091 | 1.00 | ATM (0.41) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL7849694 | 0.74 | MAPT (0.39) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL3375626 | 0.72 | MAPT (0.42) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL27791882 | 0.72 | KMT2A (0.45) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL3009386 | 0.70 | CYP1A2 (0.43) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL29770797 | 0.70 | CA12 (0.44) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL27437344 | 0.70 | AKT1 (0.43) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL3592587 | 0.70 | CA12 (0.48) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL3592585 | 0.70 | CA12 (0.48) | ATMAKT1CA12CA1CA7 | |
| SCHEMBL2067964 | 0.70 | IDO1 (0.43) | ATMAKT1CA12CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1015439-B1 | PRENYL TRANSFERASE INHIBITORS | SOD CONSEILS RECH APPLIC (FR) | 2007-04-11 | — | — | EP | disclosed |
| EP-1676855-A2 | Prenyl transferase inhibitors | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES S.A. (S.C.R.A.S.) (FR) | 2006-07-05 | — | — | EP | disclosed |
| US-6313109-B2 | ANTIPROLIFERATIVE AGENTS; TREATING TUMORS, RESTENOSIS | SOCIETE DE CONSEILS DE RECHERCHES D'APPLICATIONS SCIENTIFIQUES, SAS (FR) | 2001-11-06 | — | — | US | disclosed |
| US-20010000344-A1 | Prenyl transferase inhibitors | BIOMEASURE INCORPORATED | 2001-04-19 | — | — | US | disclosed |
| US-6180619-B1 | TREATING TUMORS OR RESTENOSIS | BIOMEASURE, INCORPORATED | 2001-01-30 | — | — | US | disclosed |
| US-5767274-A | TREATING TUMORS OR RESTENOSIS | BIOMEASURE, INCORPORATED (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0784473-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1997-12-17 | — | — | EP | disclosed |
| EP-0784473-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996009820-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| US-5504115-A | MERCAPTO-GROUP CONTAINING DIPEPTIDES; ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1996-04-02 | — | — | US | disclosed |
| US-5491164-A | DOPEPTIDE ANALOGS | MERCK & CO., INC. (US) | 1996-02-13 | — | — | US | disclosed |
| EP-0664789-A4 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE. | — | 1995-09-06 | — | — | EP | disclosed |
| EP-0664789-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | Merck & Co., Inc. (a New Jersey corp.) (US) | 1995-08-02 | — | — | EP | disclosed |
| US-5352705-A | Dipeptide-based amide compounds; anticarcinogenic agents | MERCK & CO., INC. (US) | 1994-10-04 | — | — | US | disclosed |
| WO-1994000419-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1994-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000344-A1 | Prenyl transferase inhibitors | FNTA, FNTB, RCE1 | ATM 3565/4885AKT1 260/4885CA12 4541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.