Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.37 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5443779 | 0.82 | CHEK1 (0.46) | CHEK1BTK | |
| SCHEMBL4891384 | 0.80 | CHEK1 (0.45) | CHEK1BTK | |
| SCHEMBL14269691 | 0.77 | CHEK1 (0.54) | CHEK1KDR | |
| SCHEMBL4888644 | 0.74 | BTK (0.46) | HDAC3HDAC1BTKHDAC2HDAC8 | |
| SCHEMBL5442086 | 0.69 | BTK (0.50) | HDAC3HDAC1BTK | |
| SCHEMBL4884350 | 0.68 | HTT (0.49) | HDAC3HDAC1KDRBTKHDAC2 | |
| SCHEMBL4884627 | 0.68 | BTK (0.52) | CHEK1HDAC3HDAC1KDRBTK | |
| SCHEMBL142414 | 0.66 | CHEK1 (0.58) | CHEK1KDR | |
| SCHEMBL5480003 | 0.66 | KDR (0.67) | KDR | |
| SCHEMBL5447656 | 0.66 | KDR (0.57) | HDAC3HDAC1KDRBTKHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | MERCK & CO., INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054921-A1 | Substituted indoles and a process for preparing substituted indoles | IDO1, IDO2, TPH1 | CHEK1 3120/4885HDAC3 3727/4885HDAC1 3150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.