Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 9/20 | 0.98 |
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.98 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.98 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.98 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.98 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.98 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.74 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.74 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.74 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL548094 | 1.00 | OPRD1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL9324126 | 0.99 | OPRM1 (0.98) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1276342 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL8218174 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL12638890 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1560699 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL13696342 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL14371354 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL21077535 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3257 | 0.99 | OPRD1 (1.00) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 526 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106265493-A | Improve the pharmaceutical composition of Codeine Hydrochloride drug injection preparation stability | 成都佳迪璐莎生物科技有限公司 | 2017-01-04 | — | — | CN | claimed |
| CN-106176588-A | Improve the preparation method of composition of Codeine Hydrochloride ejection preparation stability | 成都佳迪璐莎生物科技有限公司 | 2016-12-07 | — | — | CN | claimed |
| CN-101474148-B | Oral liquid sustained-release preparation containing codeine and chlorphenamine and preparation method thereof | Shenzhen zhijun pharmaceutical co ltd | 2012-11-14 | — | — | CN | claimed |
| CN-101474148-A | Oral liquid sustained-release preparation containing codeine and chlorphenamine and preparation method thereof | SHENZHEN ZHIJUN PHARMACEUTICAL (CN) | 2009-07-08 | — | — | CN | claimed |
| EP-2043613-A1 | SOLID FORM | FMC CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| US-20080311162-A1 | Solid form | FMC CORPORATION | 2008-12-18 | — | — | US | claimed |
| US-20080286343-A1 | Solid form | FMC CORPORATION | 2008-11-20 | — | — | US | claimed |
| WO-2008140460-A1 | SOLID FORM | FMC CORPORATION (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140459-A1 | SOLID FORM | FMC CORPORATION (US) | 2008-11-20 | — | — | WO | claimed |
| WO-2008140461-A1 | SOLID FORM | FMC CORPORATION (US) | 2008-11-20 | — | — | WO | claimed |
| US-20080286344-A1 | Solid form | FMC CORPORATION | 2008-11-20 | — | — | US | claimed |
| CN-100369607-C | Oral liquor slow releasing preparation containing codeine and chlorophenamine and its preparing method | SHENZHEN CITY PHARMACEUTICAL F (CN) | 2008-02-20 | — | — | CN | claimed |
| WO-2008008120-A1 | SOLID FORM | FMC CORPORATION (US) | 2008-01-17 | — | — | WO | claimed |
| US-20080014228-A1 | Solid form | FMC CORPORATION | 2008-01-17 | — | — | US | claimed |
| CN-1853693-A | Antidiarrheal medicinal composition | YANG LIBIN (CN) | 2006-11-01 | — | — | CN | claimed |
| CN-1820752-A | Oral liquor slow releasing preparation containing codeine and chlorophenamine and its preparing method | SHENZHEN CITY PHARMACEUTICAL F (CN) | 2006-08-23 | — | — | CN | claimed |
| US-20050048164-A1 | Chewing gum core overcoated with active powder materials containing anseptics, cooling compound, flavor intensifier, sweetening , enzyme, drug | STAHL BRONISLAW-JAN (DK) | 2005-03-03 | — | — | US | claimed |
| EP-1495681-A2 | A coated chewing gum, a method for preparation thereof and the use of one or more active substances in the coating | DANDY A/S (DK) | 2005-01-12 | — | — | EP | claimed |
| CN-1042598-C | Antitussive and expectorant preparation consisting of codeine and root of ballon flower | QINGHAI PHARMACEUTICAL PLANT (CN) | 1999-03-24 | — | — | CN | claimed |
| CN-1088799-A | The relieving cough and expelling phlegm agent that codeine Radix Platycodonis is formed | QINGHAI PHARMACEUTIC PLANT (CN) | 1994-07-06 | — | — | CN | claimed |