Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 5/20 | 0.64 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL72972 | 0.83 | NHERF1 (0.54) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL28577422 | 0.81 | MEN1 (0.65) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL73753 | 0.81 | NHERF1 (0.51) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL20567854 | 0.80 | NPC1 (0.68) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL27075304 | 0.80 | NPC1 (0.68) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL397016 | 0.79 | CFTR (0.78) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL2436159 | 0.78 | ITGB1 (0.55) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL2430369 | 0.78 | NPC1 (0.50) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL397563 | 0.78 | CFTR (1.00) | CFTRNHERF1NPC1MEN1KMT2A | |
| SCHEMBL20567514 | 0.78 | NPC1 (0.65) | CFTRNHERF1NPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265606-B9 | CELL ADHESION INHIBITORS | BIOGEN IDEC INC (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1741428-A2 | Cell adhesion inhibitors | Biogen Idec MA, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1265606-B1 | CELL ADHESION INHIBITORS | BIOGEN IDEC INC (US) | 2006-10-25 | — | — | EP | disclosed |
| US-20060166961-A1 | Cell adhesion inhibitors | BIOGEN IDEC MA INC. (US) | 2006-07-27 | — | — | US | disclosed |
| US-7034043-B2 | Cell adhesion inhibitors | BIOGEN IDEC MA INC. (US) | 2006-04-25 | — | — | US | disclosed |
| US-20040132809-A1 | Cell adhesion inhibitors | BIOGEN, INC. | 2004-07-08 | — | — | US | disclosed |
| US-6630503-B1 | Non-peptidic sulfonamide compounds that specifically inhibit the binding of ligands to VLA-4 for inhibition, prevention and suppression of VLA-4-mediated cell adhesion and pathologies such as inflammation and immune reactions | BIOGEN, INC. | 2003-10-07 | — | — | US | disclosed |
| EP-1265606-A4 | CELL ADHESION INHIBITORS | BIOGEN INC (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-1265606-A1 | CELL ADHESION INHIBITORS | BIOGEN, INC. (US) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001012186-A1 | CELL ADHESION INHIBITORS | BIOGEN, INC. (US) | 2001-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132809-A1 | Cell adhesion inhibitors | VCAM1, ICAM1, EPCAM | CFTR 4038/4885NHERF1 735/4885NPC1 2287/4885 |
| US-20060166961-A1 | Cell adhesion inhibitors | VCAM1, ICAM1, EPCAM | CFTR 3629/4885NHERF1 615/4885NPC1 2546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.