Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 2/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5481706 | 0.98 | CHRM5 (0.56) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL975271 | 0.80 | CHRM5 (0.59) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL1023592 | 0.75 | CHRM5 (0.57) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL4711520 | 0.75 | SIGMAR1 (0.65) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL1904710 | 0.75 | ALDH1A1 (0.69) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL12676423 | 0.75 | CHRM5 (0.53) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL14369164 | 0.74 | SIGMAR1 (0.63) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL10698614 | 0.74 | SIGMAR1 (0.63) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL255190 | 0.74 | CHRM5 (1.00) | CHRM5CHRM3SIGMAR1MEN1KMT2A | |
| SCHEMBL2007992 | 0.73 | CHRM5 (0.67) | CHRM5CHRM3SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1861376-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES AND THEIR USE AS ANTI-CANCER MEDICAMENTS | F. Hoffmann-Roche AG (CH) | 2007-12-05 | — | — | EP | disclosed |
| EP-1753727-A1 | NOVEL CIS-IMIDAZOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| WO-2006097261-A1 | CIS-2,4,5-TRIARYL-IMIDAZOLINES AND THEIR USE AS ANTI-CANCER MEDICAMENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-09-21 | — | — | WO | disclosed |
| WO-2005110996-A1 | NOVEL CIS-IMIDAZOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-11-24 | — | — | WO | disclosed |