Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6912201 | 0.79 | MAPT (0.55) | MTNR1AMTNR1BMAPTL3MBTL1 | |
| SCHEMBL5139867 | 0.78 | HDAC3 (0.50) | MAPTL3MBTL1CA9 | |
| SCHEMBL4395151 | 0.78 | CTSS (0.44) | MAPTCA12CA4CA7CA9 | |
| SCHEMBL4395154 | 0.78 | CTSS (0.44) | MAPTCA12CA4CA7CA9 | |
| SCHEMBL9217667 | 0.75 | MAPT (0.47) | MAPT | |
| SCHEMBL9243898 | 0.73 | MAPT (0.49) | MTNR1AMTNR1BMAPTL3MBTL1HTT | |
| SCHEMBL18238679 | 0.73 | L3MBTL1 (0.51) | MTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL8719529 | 0.72 | MAPT (0.47) | MTNR1AMTNR1BMAPT | |
| SCHEMBL11354893 | 0.72 | MAPT (0.47) | MAPTNPSR1 | |
| SCHEMBL21294127 | 0.71 | MAPT (0.47) | MTNR1AMTNR1BMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737471-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF LIPOPHILIC, SILICON-SUBSTITUTED, CYCLOOXYGENASE-2 SELECTIVE NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND DERIVATIVES | RND Pharmaceuticals (US) | 2007-01-03 | — | — | EP | claimed |
| WO-2005102358-A2 | SILICONE-SUBSTITUTED COX-2 SELECTIVE INHIBITORS | RND PHARMACEUTICALS (US) | 2005-11-03 | — | — | WO | claimed |