Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.67 |
| ▸ | HRH2 | P25021 | 1/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5480208 | 0.93 | KCNA5 (0.74) | DRD2HRH2HRH1MEN1KMT2A | |
| SCHEMBL4743140 | 0.89 | HRH3 (0.65) | DRD2HRH1MEN1KMT2AKCNA5 | |
| SCHEMBL15349833 | 0.87 | KDM4E (0.70) | DRD2HRH1MEN1KMT2AKCNA5 | |
| SCHEMBL5487964 | 0.86 | DRD2 (0.51) | DRD2HRH2HRH1MEN1KMT2A | |
| SCHEMBL20512382 | 0.86 | DRD2 (0.56) | DRD2HRH2HRH1KCNA5HRH3 | |
| SCHEMBL2234336 | 0.84 | HRH3 (0.59) | DRD2MEN1KMT2AKCNA5HRH3 | |
| SCHEMBL3985948 | 0.84 | HRH3 (0.67) | MEN1KMT2AHRH3ALDH1A1 | |
| SCHEMBL6471513 | 0.83 | HRH3 (0.75) | HRH3ALDH1A1 | |
| SCHEMBL9809270 | 0.82 | HRH2 (0.69) | DRD2HRH2HRH1MEN1KMT2A | |
| SCHEMBL5487159 | 0.81 | TSHR (0.55) | DRD2HRH2HRH1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | claimed |
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | disclosed |
| EP-1720848-A1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | Sanofi-Aventis (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005090322-A1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI-AVENTIS (FR) | 2005-09-29 | — | — | WO | disclosed |