Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3985948 | 0.87 | HRH3 (0.67) | HRH3KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5481509 | 0.86 | DRD2 (0.67) | DRD2HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL15349833 | 0.81 | KDM4E (0.70) | DRD2HRH1HRH3KDM4EALDH1A1 | |
| SCHEMBL5487159 | 0.79 | TSHR (0.55) | DRD2HRH2HRH1KDM4EALDH1A1 | |
| SCHEMBL5480294 | 0.79 | HPGD (0.61) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5480208 | 0.78 | KCNA5 (0.74) | DRD2HRH2HRH1HRH3ALDH1A1 | |
| SCHEMBL2179409 | 0.78 | HRH2 (0.55) | HRH2HRH1HRH3 | |
| SCHEMBL20512382 | 0.77 | DRD2 (0.56) | DRD2HRH2HRH1HRH3KDM4E | |
| SCHEMBL5480360 | 0.76 | POLB (0.58) | DRD2HRH2HRH1KDM4EALDH1A1 | |
| SCHEMBL4743140 | 0.76 | HRH3 (0.65) | DRD2HRH1HRH3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | claimed |
| EP-1720848-B1 | DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINE- CARBOXYLATES, PREPARATION METHOD THEREOF AND USE OF SAME AS FAAH ENZYME INHIBITORS | SANOFI AVENTIS (FR) | 2007-12-05 | — | — | EP | disclosed |