Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 10/20 | 0.67 |
| ▸ | CDK2 | P24941 | 10/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.67 |
| ▸ | GLS | O94925 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131310 | 0.89 | CCNE1 (0.78) | CCNE1CDK2CDK5LMNANPC1 | |
| SCHEMBL5480770 | 0.83 | CCNE1 (0.55) | CCNE1CDK2CDK5GLSLMNA | |
| SCHEMBL5836526 | 0.80 | CCNE1 (0.64) | CCNE1CDK2CDK5GLSLMNA | |
| SCHEMBL5487337 | 0.80 | CCNE1 (0.58) | CCNE1CDK2CDK5GLSLMNA | |
| SCHEMBL6706074 | 0.79 | CCNE1 (1.00) | CCNE1CDK2CDK5GLSCDK5R1 | |
| SCHEMBL5835965 | 0.78 | LMNA (0.65) | CCNE1CDK2CDK5LMNANPC1 | |
| SCHEMBL2753861 | 0.78 | LMNA (0.73) | CCNE1CDK2CDK5GLSLMNA | |
| SCHEMBL5477005 | 0.78 | CCNE1 (0.73) | CCNE1CDK2CDK5GLSLMNA | |
| SCHEMBL28155418 | 0.78 | LMNA (0.72) | CCNE1CDK2CDK5LMNANPC1 | |
| SCHEMBL10009245 | 0.77 | SIRT2 (0.65) | CCNE1CDK2CDK5LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1204649-B1 | ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-10-17 | — | — | EP | claimed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| EP-1204649-B1 | ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-10-17 | — | — | EP | disclosed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |