Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.64 |
| ▸ | CDK2 | P24941 | 3/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.64 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
| ▸ | RELA | Q04206 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10009245 | 0.88 | SIRT2 (0.65) | LMNANPC1RAB9ATP53CCNE1 | |
| SCHEMBL3131310 | 0.85 | CCNE1 (0.78) | LMNANPC1RAB9ATP53CCNE1 | |
| SCHEMBL28155418 | 0.83 | LMNA (0.72) | LMNANPC1RAB9ATP53CCNE1 | |
| SCHEMBL2753637 | 0.83 | ALDH1A1 (0.74) | LMNANPC1RAB9ASIRT2SMN1; SMN2 | |
| SCHEMBL10008562 | 0.81 | LMNA (0.71) | LMNANPC1RAB9ATP53CCNE1 | |
| SCHEMBL10007768 | 0.81 | ABL1 (0.61) | LMNANPC1RAB9ATP53CCNE1 | |
| SCHEMBL28027577 | 0.80 | LMNA (0.72) | LMNANPC1RAB9ATP53CCNE1 | |
| SCHEMBL3185786 | 0.79 | LMNA (0.61) | LMNANPC1RAB9ATP53CCNE1 | |
| SCHEMBL5835925 | 0.79 | ALDH1A1 (0.62) | LMNANPC1RAB9ACCNE1CDK2 | |
| SCHEMBL10009298 | 0.79 | LMNA (0.55) | LMNANPC1RAB9ATP53CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | claimed |
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| CN-1325389-A | 2-aminothiazole derivatives, process for preparing the same and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2001-12-05 | — | — | CN | disclosed |