SCHEMBL5482138

SCHEMBL5482138

CCOC(=O)C(C)(C)Oc1c(C)cc(CNCC(=O)N(C)Cc2nc(-c3cccc(Cl)c3)oc2C)cc1C

nearest known ligand 0.47

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 8/20 0.47
PPARG P37231 7/20 0.47
NR1H2 P55055 3/20 0.41
NR1H3 Q13133 3/20 0.41
MAPT P10636 2/20 0.41
TP53 P04637 2/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5485451 0.93 PPARA (0.54) PPARAPPARGMAPTTP53
SCHEMBL5475387 0.92 PPARA (0.46) PPARAPPARGMAPTTP53
SCHEMBL5482142 0.88 PPARG (0.51) PPARAPPARGNR1H2NR1H3MAPT
SCHEMBL5482148 0.86 TP53 (0.50) PPARAPPARGMAPTTP53SMN1; SMN2
SCHEMBL5487235 0.84 PPARA (0.54) PPARAPPARGMAPTTP53
SCHEMBL5481228 0.82 PPARG (0.56) PPARAPPARGNR1H2NR1H3
SCHEMBL5482151 0.82 PPARG (0.52) PPARAPPARGNR1H2NR1H3MAPT
SCHEMBL5481594 0.81 PPARG (0.52) PPARAPPARGNR1H2NR1H3MAPT
SCHEMBL5484127 0.80 PPARA (0.60) PPARAPPARGNR1H2NR1H3
SCHEMBL14414920 0.80 PPARA (0.62) PPARAPPARGMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
EP-1731513-A1 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD PPARA 1/4885PPARG 2/4885NR1H2 21/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.