Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.63 |
| ▸ | CA1 | P00915 | 6/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.53 |
| ▸ | CA9 | Q16790 | 6/20 | 0.53 |
| ▸ | CA12 | O43570 | 4/20 | 0.53 |
| ▸ | CA4 | P22748 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.53 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4880685 | 0.87 | PTGS2 (0.77) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL6832160 | 0.83 | PTGS2 (0.76) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL2279510 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL8475898 | 0.79 | PTGS2 (0.61) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL13524347 | 0.78 | PTGS2 (0.73) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL30901200 | 0.78 | PTGS2 (0.76) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL30901199 | 0.78 | PTGS2 (0.76) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL28679825 | 0.78 | PTGS2 (0.76) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL4891953 | 0.78 | PTGS2 (0.78) | PTGS2PTGS1CA1CA2CA9 | |
| SCHEMBL28397844 | 0.77 | PTGS2 (0.78) | PTGS2PTGS1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070072921-A1 | CRYSTALLINE FORM OF 4-[5-METHYL-3-PHENYLISOXAZOL-4-YL] BENZENESULFONAMIDE | TALLEY JOHN J | 2007-03-29 | — | — | US | disclosed |
| EP-1283203-A1 | Crystalline form of 4-(5-methyl-3-phenylisoxazol-4-yl) benzene-sulfonamide | G.D. SEARLE & CO. (US) | 2003-02-12 | — | — | EP | disclosed |
| US-20030004200-A1 | Cyclooxygenase inhibitors; antiinflammatory agents | G.D. SEARLE & CO. | 2003-01-02 | — | — | US | disclosed |
| EP-0920422-B1 | CRYTALLINE FORM OF 4-[5-METHYL-3-PHENYLISOXAZOL-4-YL]BENZENESULFONAMIDE | SEARLE & CO (US) | 2002-11-20 | — | — | EP | disclosed |
| US-20010003752-A1 | Antiinflammatory agent, useful for treating cylcoocygenase-2 associated disorders | G.D. SEARLE & CO. (US) | 2001-06-14 | — | — | US | disclosed |
| EP-0920422-A1 | CRYTALLINE FORM OF 4-[5-METHYL-3-PHENYLISOXAZOL-4-YL]BENZENESULFONAMIDE | G.D. SEARLE & CO. (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006708-A1 | CRYSTALLINE FORM OF 4-[5-METHYL-3-PHENYLISOXAZOL-4-YL]BENZENESULFONAMIDE | G.D. SEARLE & CO. (US) | 1998-02-19 | — | — | WO | disclosed |