SCHEMBL5482494

SCHEMBL5482494

Cc1ccc(C2CC(=O)CC(=O)C2)cc1F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.47
GAA P10253 1/20 0.47
SIRT2 Q8IXJ6 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.38
RIPK1 Q13546 1/20 0.38
SLC6A2 P23975 3/20 0.38
SLC6A4 P31645 3/20 0.38
SLC6A3 Q01959 3/20 0.38
TDP1 Q9NUW8 2/20 0.37
CHRNA1 P02708 1/20 0.35
CHRNG P07510 1/20 0.35
ITGA5 P08648 1/20 0.35
CHRNB1 P11230 1/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA4 P43681 1/20 0.35
CHRND Q07001 1/20 0.35
TP53 P04637 1/20 0.35
RECQL P46063 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29008633 0.87 RIPK1 (0.39) MAPTGAASIRT2L3MBTL1RIPK1
SCHEMBL11832979 0.86 MAPT (0.47) MAPTGAAL3MBTL1SLC6A2SLC6A4
SCHEMBL30368437 0.86 MAPT (0.47) MAPTGAAL3MBTL1SLC6A2SLC6A4
SCHEMBL25374797 0.85 RIPK1 (0.36) MAPTGAASIRT2RIPK1SLC6A2
SCHEMBL29496819 0.84 MAPT (0.52) MAPTGAAL3MBTL1TDP1TP53
SCHEMBL13454021 0.84 MAPT (0.52) MAPTGAAL3MBTL1TDP1TP53
SCHEMBL7005994 0.83 PDE4A (0.47) SIRT2RIPK1SLC6A2SLC6A4SLC6A3
SCHEMBL30368484 0.79 GAA (0.47) MAPTGAAL3MBTL1TDP1TP53
SCHEMBL5422791 0.79 MAPT (0.47) MAPTGAARIPK1SLC6A2SLC6A4
SCHEMBL30368131 0.79 SLC6A2 (0.49) MAPTGAASIRT2L3MBTL1SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12509579-B2 Thermoplastic resin and optical lens including same MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2025-12-30 US disclosed
CN-115996931-B Cyclic diol compound, process for producing the compound, and use of the compound 新日本理化株式会社 2025-04-01 CN disclosed
US-20230399510-A1 THERMOPLASTIC RESIN AND OPTICAL LENS INCLUDING SAME MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2023-12-14 US disclosed
EP-4239010-A1 THERMOPLASTIC RESIN AND OPTICAL LENS INCLUDING SAME MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2023-09-06 EP disclosed
CN-116323753-A Thermoplastic resin and optical lens comprising the same 三菱瓦斯化学株式会社 2023-06-23 CN disclosed
CN-115996931-A Cyclic diol compound, process for producing the compound, and use of the compound 新日本理化株式会社 2023-04-21 CN disclosed
US-20070112015-A1 Substituted dihydropyridines and methods of use CHEMOCENTRYX, INC. (US) 2007-05-17 US disclosed
US-20070112015-A1 Substituted dihydropyridines and methods of use CHEMOCENTRYX, INC. (US) 2007-05-17 US disclosed
US-20070112015-A1 Substituted dihydropyridines and methods of use CHEMOCENTRYX, INC. (US) 2007-05-17 US disclosed
WO-2007051062-A2 SUBSTITUTED DIHYDROPYRIDINES AND METHODS OF USE CHEMOCENTRYX, INC. (US) 2007-05-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12509579-B2 Thermoplastic resin and optical lens including same RIF1, POT1, LAS1L MAPT 932/4885GAA 921/4885SIRT2 3790/4885
US-20070112015-A1 Substituted dihydropyridines and methods of use C3AR1, C5AR1, C5AR2 MAPT 4656/4885GAA 3421/4885SIRT2 1997/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.