Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 3/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5486178 | 0.91 | KDM4A (0.36) | SLC6A4SLC6A2SLC6A3PPARGPPARD | |
| SCHEMBL5485960 | 0.91 | SSTR5 (0.38) | SLC6A4SLC6A2SLC6A3PPARGPPARD | |
| SCHEMBL5481894 | 0.83 | SSTR5 (0.38) | SLC6A4SLC6A2SLC6A3PPARGPPARD | |
| SCHEMBL5498410 | 0.82 | SLC6A2 (0.38) | SLC6A4SLC6A2SLC6A3PPARGPPARD | |
| SCHEMBL4866640 | 0.82 | MAPT (0.41) | SLC6A4SLC6A2SLC6A3HRH1HTR2B | |
| SCHEMBL5485921 | 0.82 | PDE10A (0.36) | SLC6A4SLC6A2SLC6A3PDE10AKCNH2 | |
| SCHEMBL4593259 | 0.76 | SSTR5 (0.42) | SLC6A4SLC6A2SLC6A3TACR1HRH1 | |
| SCHEMBL5486981 | 0.75 | SSTR5 (0.37) | SLC6A4SLC6A2SLC6A3TACR1KCNH2 | |
| SCHEMBL4594422 | 0.75 | REN (0.42) | PDE10AREN | |
| SCHEMBL4593346 | 0.75 | PPARG (0.35) | SLC6A4SLC6A2SLC6A3PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |