Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5486670 | 0.92 | CETP (0.39) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5485960 | 0.91 | SSTR5 (0.38) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL4866640 | 0.91 | MAPT (0.41) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5485921 | 0.88 | PDE10A (0.36) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5492474 | 0.84 | POLB (0.42) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL1121565 | 0.84 | SSTR5 (0.45) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5481894 | 0.83 | SSTR5 (0.38) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5488867 | 0.83 | SSTR5 (0.38) | SLC6A2SLC6A4SLC6A3KCNH2SSTR5 | |
| SCHEMBL5482720 | 0.82 | SLC6A4 (0.36) | SLC6A2SLC6A4SLC6A3KCNH2TACR1 | |
| SCHEMBL5483266 | 0.82 | MAPT (0.46) | KDM4EMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |