Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129869 | 0.84 | PRKCI (0.62) | HRH3CYP11B1CYP11B2CYP19A1PRKCI | |
| SCHEMBL21375425 | 0.82 | IDO1 (0.59) | AGXTIDO1GGPS1AOC3HRH3 | |
| SCHEMBL332301 | 0.81 | MEN1 (0.48) | IDO1CYP19A1MAOAMAOBTAAR1 | |
| SCHEMBL6267935 | 0.79 | FFAR1 (0.54) | AGXTIDO1HRH3TAAR1 | |
| SCHEMBL7365145 | 0.78 | ALDH1A1 (0.65) | AGXTGPR84GGPS1AOC3HRH3 | |
| SCHEMBL5865103 | 0.78 | AGXT (0.52) | AGXTGPR84GGPS1AOC3CYP11B1 | |
| SCHEMBL5865105 | 0.78 | TDP1 (0.62) | AGXTGPR84GGPS1AOC3HRH3 | |
| SCHEMBL11358683 | 0.78 | TDP1 (0.62) | AGXTGPR84GGPS1AOC3HTR7 | |
| SCHEMBL4533749 | 0.78 | AGXT (0.52) | AGXTGPR84GGPS1AOC3HTR7 | |
| SCHEMBL29618101 | 0.78 | SIGMAR1 (0.52) | AGXTMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7220780-B2 | Naaladase inhibitors for treating retinal disorders and glaucoma | GUILFORD PHARMACEUTICALS INC. (US) | 2007-05-22 | — | — | US | disclosed |