Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TYR | P14679 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8232813 | 1.00 | GRM5 (0.47) | GRM5IDO1TDO2PGRALDH1A1 | |
| SCHEMBL14363428 | 0.79 | GRM5 (0.48) | GRM5IDO1TDO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4051271 | 0.79 | GRM5 (0.48) | GRM5IDO1TDO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2895174 | 0.78 | GRM5 (0.47) | GRM5IDO1TDO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2893471 | 0.78 | GRM5 (0.47) | GRM5IDO1TDO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2893177 | 0.78 | GRM5 (0.47) | GRM5IDO1TDO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2893451 | 0.78 | GRM5 (0.47) | GRM5IDO1TDO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL27770577 | 0.76 | GRM5 (0.46) | GRM5IDO1TDO2ALDH1A1SMN1; SMN2 | |
| SCHEMBL27770576 | 0.76 | PKM (0.48) | GRM5ALDH1A1SMN1; SMN2PKMLMNA | |
| SCHEMBL5491722 | 0.73 | GRM5 (0.45) | GRM5ALDH1A1SMN1; SMN2PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | claimed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | GRM5, GRIK5, GRM2 | GRM5 1/4885IDO1 4442/4885TDO2 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.