Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4446190 | 0.87 | DGAT1 (0.56) | DGAT1PARP1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL7424346 | 0.84 | DGAT1 (0.58) | DGAT1PARP1KMT2AMEN1CYP1A2 | |
| SCHEMBL3206015 | 0.84 | POLB (0.47) | POLBCTDSP1KMT2AMEN1CYP1A2 | |
| SCHEMBL15197077 | 0.84 | PTGDR2 (0.44) | DGAT1POLBCTDSP1KMT2AMEN1 | |
| SCHEMBL24699357 | 0.82 | ALDH1A1 (0.38) | DGAT1POLBCTDSP1KMT2AMEN1 | |
| SCHEMBL7409664 | 0.81 | PRKCI (0.40) | POLBKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL22067721 | 0.81 | MAPK8 (0.39) | PARP1KMT2AMEN1ALDH1A1HSD17B10 | |
| SCHEMBL2977013 | 0.81 | HSD17B10 (0.42) | PARP1KMT2AMEN1CYP1A2CYP2D6 | |
| SCHEMBL504526 | 0.80 | DGAT1 (0.56) | DGAT1PARP1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL27761984 | 0.80 | DGAT1 (0.56) | DGAT1PARP1POLBCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |