⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2183951 | 0.82 | FAAH (0.40) | — | |
| SCHEMBL11680465 | 0.80 | FAAH (0.39) | — | |
| SCHEMBL7111335 | 0.78 | — | — | |
| SCHEMBL366668 | 0.78 | — | — | |
| SCHEMBL10978747 | 0.78 | ALDH1A1 (0.45) | — | |
| SCHEMBL11150573 | 0.78 | — | — | |
| SCHEMBL19334823 | 0.78 | — | — | |
| SCHEMBL11409673 | 0.77 | — | — | |
| SCHEMBL9704463 | 0.76 | — | — | |
| SCHEMBL10827899 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170107229-A1 | SUBSTITUTED TETRAHYDROPYRIDOTHIENOPYRIMIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-04-20 | — | — | US | disclosed |
| EP-3149004-A1 | SUBSTITUTED TETRAHYDROPYRIDOTHIENOPYRIMIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-04-05 | — | — | EP | disclosed |
| WO-2015181063-A1 | SUBSTITUTED TETRAHYDROPYRIDOTHIENOPYRIMIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2015-12-03 | — | — | WO | disclosed |
| US-7291622-B2 | Medical uses of carbamate-substituted pyrazolo-pyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2007-11-06 | — | — | US | disclosed |
| US-7105523-B2 | Carbamate-substituted pyrazolopyridine-derivatives | BAYER AKTIENGESELISCHAFT (DE) | 2006-09-12 | — | — | US | disclosed |
| US-20050261323-A1 | Medical uses of novel carbamate-substituted pyrazolopyridine derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2005-11-24 | — | — | US | disclosed |