SCHEMBL5484160

SCHEMBL5484160

Cc1cccc(-c2oc(-c3cccc(Br)c3)nc2CCl)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 8/20 0.47
RAB9A P51151 8/20 0.47
SMN1; SMN2 Q16637 5/20 0.47
MEN1 O00255 3/20 0.47
KMT2A Q03164 3/20 0.47
MAPT P10636 3/20 0.47
KDM4E B2RXH2 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
GAA P10253 1/20 0.47
TSHR P16473 2/20 0.44
TP53 P04637 2/20 0.44
HPGD P15428 1/20 0.44
PPARG P37231 3/20 0.42
PPARA Q07869 3/20 0.42
MAOB P27338 2/20 0.42
PBRM1 Q86U86 1/20 0.41
RXFP1 Q9HBX9 2/20 0.41
ALDH1A1 P00352 2/20 0.40
CYP1A2 P05177 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5103142 0.82 RXFP1 (0.52) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL1436140 0.79 MAPT (0.49) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL6989552 0.75 PPARG (0.54) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL4471443 0.74 NPC1 (0.54) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL1050208 0.74 RAB9A (0.53) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL9755249 0.72 ALDH1A1 (0.50) NPC1RAB9ASMN1; SMN2KMT2AMAPT
SCHEMBL3973842 0.71 RXFP1 (0.52) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL5479662 0.71 RXFP1 (0.52) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL10341496 0.71 ALDH1A1 (0.49) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL5099375 0.70 KDM4E (0.72) NPC1RAB9AMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same DAIICHI PHARMACEUTICAL CO., LTD. 2007-09-06 US disclosed
EP-1731513-A1 PHENOXYACETIC ACID DERIVATIVE AND MEDICINE CONTAINING THE SAME DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-12-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070208021-A1 Phenoxyacetic Acid Derivatives and Drug Comprising The Same PPARA, PPARG, PPARD NPC1 2452/4885RAB9A 1383/4885SMN1; SMN2 4822/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.