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SCHEMBL5484352

SCHEMBL5484352

Cc1ncc(NC(=O)c2cc(N3CCOCC3)cc(C(F)(F)F)c2)cc1C(=O)Nc1ccc(NCC2CCCO2)nc1

nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ CSF1R P07333 3/20 0.50
▸ RAF1 P04049 15/20 0.49
▸ BRAF P15056 15/20 0.49
▸ MAPK14 Q16539 2/20 0.46
▸ LYN P07948 1/20 0.46
▸ TNK2 Q07912 1/20 0.45
▸ MAP4K2 Q12851 1/20 0.45
▸ LCK P06239 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4565879 0.91 MAPK14 (0.47) RAF1BRAFMAPK14TNK2
SCHEMBL4417256 0.91 RAF1 (0.52) CSF1RRAF1BRAFMAPK14
SCHEMBL4409370 0.90 RAF1 (0.51) CSF1RRAF1BRAFMAPK14
SCHEMBL4551612 0.90 RAF1 (0.52) CSF1RRAF1BRAFMAPK14
SCHEMBL4551790 0.87 HCAR3 (0.45) MAPK14TNK2LCK
SCHEMBL4411276 0.86 RAF1 (0.53) CSF1RRAF1BRAFTNK2MAP4K2
SCHEMBL4551562 0.86 HCAR3 (0.44) MAPK14TNK2LCK
SCHEMBL5490015 0.86 RAF1 (0.52) CSF1RRAF1BRAF
SCHEMBL5490162 0.85 TNK2 (0.44) CSF1RRAF1BRAFMAPK14TNK2
SCHEMBL5484353 0.83 RAF1 (0.48) CSF1RRAF1BRAFMAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007056016-A2 BISAMIDE CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-05-18 — — WO disclosed
WO-2007056016-A2 BISAMIDE CYTOKINE INHIBITORS KEMIA, INC. (US) 2007-05-18 — — WO disclosed