Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.42 |
| ▸ | SMO | Q99835 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551562 | 0.99 | HCAR3 (0.44) | HCAR3MAPK14SMOCXCR2TNK2 | |
| SCHEMBL4565879 | 0.96 | MAPK14 (0.47) | HCAR3MAPK14TNK2 | |
| SCHEMBL5490598 | 0.89 | CRHR1 (0.50) | MAPK14SMOSMN1; SMN2TSHRHTT | |
| SCHEMBL5490935 | 0.89 | CRHR1 (0.45) | MAPK14SMOCRHR1LCKKDR | |
| SCHEMBL5489512 | 0.89 | CRHR1 (0.49) | MAPK14SMOSMN1; SMN2TSHRHTT | |
| SCHEMBL14534448 | 0.88 | HCAR3 (0.40) | HCAR3MAPK14SMOCXCR2TNK2 | |
| SCHEMBL4551651 | 0.88 | CRHR1 (0.45) | MAPK14SMOSMN1; SMN2HTTCRHR1 | |
| SCHEMBL5488464 | 0.88 | CRHR1 (0.47) | MAPK14SMOSMN1; SMN2TSHRHTT | |
| SCHEMBL5487267 | 0.88 | CRHR1 (0.47) | MAPK14SMOSMN1; SMN2TSHRHTT | |
| SCHEMBL5484352 | 0.87 | CSF1R (0.50) | MAPK14TNK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |