Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 7/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 12/20 | 0.46 |
| ▸ | BRAF | P15056 | 6/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593401 | 1.00 | PLAU (0.48) | PLAURAF1MAPK14BRAFMAPK13 | |
| SCHEMBL4409060 | 0.80 | MAPK14 (0.54) | PLAURAF1MAPK14BRAFMAPK13 | |
| SCHEMBL15074587 | 0.80 | PLAU (0.57) | PLAURAF1MAPK14BRAFMAPK13 | |
| SCHEMBL5484374 | 0.79 | MAPK14 (0.51) | PLAURAF1MAPK14BRAFMAPK13 | |
| SCHEMBL4551755 | 0.77 | PLAU (0.48) | PLAURAF1MAPK14BRAFMAPK13 | |
| SCHEMBL4551497 | 0.77 | MAPK14 (0.60) | PLAURAF1MAPK14MAPK13MAPK12 | |
| SCHEMBL15070867 | 0.77 | PLAU (0.52) | PLAURAF1MAPK14BRAFMAPK13 | |
| SCHEMBL4551653 | 0.76 | DDR2 (0.55) | PLAURAF1MAPK14BRAFMAPK13 | |
| SCHEMBL4727498 | 0.76 | RAF1 (0.53) | RAF1BRAF | |
| SCHEMBL4727385 | 0.76 | RAF1 (0.56) | RAF1MAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |