Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5489140 | 0.98 | DAO (0.45) | DAOTSHRGPR35ALDH1A1CYP3A4 | |
| SCHEMBL18701570 | 0.77 | GPR35 (0.46) | DAOTSHRGPR35ALDH1A1CYP3A4 | |
| SCHEMBL18701630 | 0.77 | DAO (0.43) | DAOTSHRGPR35ALDH1A1SMN1; SMN2 | |
| SCHEMBL8083734 | 0.77 | TSHR (0.43) | DAOTSHRALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL18701669 | 0.76 | DAO (0.42) | DAOTSHRGPR35ALDH1A1SMN1; SMN2 | |
| SCHEMBL8632005 | 0.76 | DAO (0.42) | DAOTSHRGPR35ALDH1A1CYP3A4 | |
| SCHEMBL18701593 | 0.76 | TSHR (0.42) | DAOTSHRGPR35ALDH1A1CYP3A4 | |
| SCHEMBL11469443 | 0.71 | MEN1 (0.41) | DAOTSHRALDH1A1SMN1; SMN2ABL1 | |
| SCHEMBL5560977 | 0.71 | KMO (0.45) | — | |
| SCHEMBL1328328 | 0.71 | MEN1 (0.49) | DAOTSHRALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7307174-B2 | Process and intermediates for the preparation of thienopyrrole derivatives | ASTRAZENECA AB (SE) | 2007-12-11 | — | — | US | disclosed |
| US-20050272938-A1 | Process and intermediates for the preparation of thienopyrrole derivatives | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549653-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF THIENOPYRROLE DERIVATIVES | Astrazeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031193-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF THIENOPYRROLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272938-A1 | Process and intermediates for the preparation of thienopyrrole derivatives | POR, CYP3A4, CYP2C19 | DAO 2006/4885TSHR 47/4885GPR35 2659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.