Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 2/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3503161 | 0.98 | MMP3 (0.48) | MMP3TNKSNOTUMKIF11CA12 | |
| SCHEMBL3507065 | 0.88 | MMP3 (0.41) | MMP3TNKSNOTUMKIF11AR | |
| SCHEMBL11606898 | 0.87 | MMP3 (0.43) | MMP3TNKSNOTUMKIF11CA12 | |
| SCHEMBL14046685 | 0.86 | ALDH1A1 (0.43) | MMP3TNKSKIF11ALDH1A1CYP2A6 | |
| SCHEMBL3504690 | 0.86 | F2 (0.46) | MMP3TNKSNOTUMKIF11ALDH1A1 | |
| SCHEMBL398823 | 0.85 | MMP3 (0.47) | MMP3TNKSNOTUMKIF11CA12 | |
| SCHEMBL3506668 | 0.85 | F2 (0.45) | MMP3TNKSNOTUMKIF11CA12 | |
| SCHEMBL13681351 | 0.85 | ALDH1A1 (0.46) | MMP3TNKSNOTUMKIF11ALDH1A1 | |
| 4-(2,2'-Bifuran-5-Yl)Benzonitrile SCHEMBL3505610 | 0.83 | MYC (0.50) | TNKSNOTUMALDH1A1ARMAPKAPK2 | |
| SCHEMBL13167125 | 0.83 | TNKS (0.38) | MMP3TNKSNOTUMKIF11AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242059-B1 | NOVEL PRODRUGS FOR ANTIMICROBIAL AMIDINES | UNIV NORTH CAROLINA (US) | 2007-03-21 | — | — | EP | disclosed |
| EP-1685836-A2 | Antifungal activity of dicationic molecules | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-08-02 | — | — | EP | disclosed |
| US-7071338-B2 | such as 2,5-bis[4-hydroxy and 4-O-alkylamidinophenyl]furan compounds, from amidoxime compounds with 2,5-bis-tri-alkylstannannes via one step palladium-catalyzed cross reaction | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1565457-A2 | PROCESS FOR SYNTHESIS BIS-ARYL DIAMIDOXIME COMPOUNDS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-08-24 | — | — | EP | disclosed |
| US-20040127721-A1 | Process for the synthesis of bis-aryl diamidoxime compounds | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2004-07-01 | — | — | US | disclosed |
| WO-2004051217-A2 | PROCESS FOR SYNTHESIS BIS-ARYL DIAMIDOXIME COMPOUNDS | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2004-06-17 | — | — | WO | disclosed |
| US-6649652-B2 | Hypotensive agents; hyperglycemic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2003-11-18 | — | — | US | disclosed |
| US-20030092755-A1 | Novel prodrugs for antimicrobial amidines | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-05-15 | — | — | US | disclosed |
| US-6503940-B2 | Aids therapy | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2003-01-07 | — | — | US | disclosed |
| US-6486200-B1 | Prodrugs for antimicrobial amidines | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2002-11-26 | — | — | US | disclosed |
| EP-1143959-A2 | ANTIFUNGAL ACTIVITY OF DICATIONIC MOLECULES | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001003685-A2 | NOVEL PRODRUGS FOR ANTIMICROBIAL AMIDINES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-01-18 | — | — | WO | disclosed |
| WO-2000015212-A2 | ANTIFUNGAL ACTIVITY OF DICATIONIC MOLECULES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-03-23 | — | — | WO | disclosed |
| US-5935776-A | 2,5-BIS(4-(3-N,N,-DIMETHYLAMINOPROPYLAMIDINO)PHENYL)FURAN OR PHARMACEUTICALLY ACCEPTABLE SALT AND DILUENT OR CARRIER AS VIRICIDE TO SUPPRESS BINDING OF REV PROTEIN TO MESSENGER RNAS THUS SUPPRESSING REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1999-08-10 | — | — | US | disclosed |
| US-5723288-A | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-03-03 | — | — | US | disclosed |
| US-5667975-A | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans | THE UNIVERSITY OF NORTH CAROLINA | 1997-09-16 | — | — | US | disclosed |
| EP-0792271-A1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1997-09-03 | — | — | EP | disclosed |
| US-5602172-A | USING A 2,5-DIPHENYLFURAN COMPOUND | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-02-11 | — | — | US | disclosed |
| US-5594138-A | MEDICAL DIAGNOSIS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1996015126-A1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 1996-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127721-A1 | Process for the synthesis of bis-aryl diamidoxime compounds | DDT, DAO, DDO | MMP3 3430/4885TNKS 2093/4885NOTUM 1897/4885 |
| US-20030092755-A1 | Novel prodrugs for antimicrobial amidines | NR1H3, APEH, NR1H2 | MMP3 1068/4885TNKS 3004/4885NOTUM 1619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.