Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR1D | P28221 | 2/20 | 0.45 |
| ▸ | HTR1B | P28222 | 2/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398434 | 1.00 | HTR2A (0.51) | HTR2AHTR2CMEN1KMT2AHPGD | |
| SCHEMBL3103740 | 0.85 | HPGD (0.62) | HTR2AHTR2CMEN1KMT2AHPGD | |
| SCHEMBL4185239 | 0.83 | HTR2A (0.53) | HTR2AHTR2CMEN1KMT2AHPGD | |
| SCHEMBL5145582 | 0.83 | HTR2A (0.54) | HTR2AHTR2CMEN1KMT2AHPGD | |
| SCHEMBL5742536 | 0.81 | GPR84 (0.49) | HTR2AHTR2CMEN1KMT2AHPGD | |
| Dimethylamine SCHEMBL7871287 | 0.81 | HPGD (0.57) | HTR2AHTR2CMEN1KMT2AHPGD | |
| SCHEMBL29507897 | 0.81 | MEN1 (0.60) | HTR2AHTR2CMEN1KMT2AHPGD | |
| SCHEMBL2015074 | 0.81 | HTR2A (0.44) | HTR2AHTR2CMEN1KMT2AHPGD | |
| SCHEMBL27694046 | 0.81 | HTR2A (0.47) | HTR2AHTR2CMEN1KMT2AHPGD | |
| SCHEMBL4857335 | 0.81 | MEN1 (0.60) | HTR2AHTR2CMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773816-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002421-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-05 | — | — | WO | disclosed |