Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTR1D | P28221 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 5/20 | 0.53 |
| ▸ | HTR1B | P28222 | 4/20 | 0.53 |
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.44 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3103740 | 0.95 | HPGD (0.62) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| SCHEMBL8235788 | 0.81 | CYP2C19 (0.63) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| SCHEMBL5484715 | 0.81 | HTR2A (0.51) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| SCHEMBL398434 | 0.81 | HTR2A (0.51) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| SCHEMBL2841739 | 0.81 | MPO (0.68) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| Dimethylamine SCHEMBL8878578 | 0.80 | HTR2C (0.68) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| SCHEMBL9664523 | 0.79 | MPO (0.66) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| SCHEMBL14160299 | 0.79 | HTR1A (0.65) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| SCHEMBL2838886 | 0.78 | MPO (0.70) | HPGDCYP2C19HTR1DHTR1AHTR1B | |
| SCHEMBL16847275 | 0.78 | HTR1D (0.47) | HTR1DHTR1AHTR1BHTR2AGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083918-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE 5-HT RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999064044-A1 | NOVEL THERAPEUTIC AGENTS THAT MODULATE 5-HT RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |