Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491723 | 1.00 | HRH3 (0.61) | HRH3SIGMAR1ALDH1A1POLBTHRB | |
| SCHEMBL491587 | 1.00 | HRH3 (0.61) | HRH3SIGMAR1ALDH1A1POLBTHRB | |
| SCHEMBL491586 | 1.00 | HRH3 (0.61) | HRH3SIGMAR1ALDH1A1POLBTHRB | |
| SCHEMBL12741679 | 1.00 | HRH3 (0.61) | HRH3SIGMAR1ALDH1A1POLBTHRB | |
| SCHEMBL6052607 | 0.94 | SIGMAR1 (0.65) | HRH3SIGMAR1ALDH1A1 | |
| SCHEMBL491585 | 0.86 | HRH3 (0.63) | HRH3SIGMAR1SMN1; SMN2 | |
| SCHEMBL491873 | 0.86 | HRH3 (0.63) | HRH3SIGMAR1SMN1; SMN2 | |
| SCHEMBL491900 | 0.86 | HRH3 (0.63) | HRH3SIGMAR1SMN1; SMN2 | |
| SCHEMBL491602 | 0.85 | HRH3 (0.68) | HRH3ALDH1A1 | |
| SCHEMBL6052840 | 0.84 | HRH3 (0.64) | HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863487-A2 | TREATMENT OF PARKINSON'S DISEASE, OBSTRUCTIVE SLEEP APNEA, DEMENTIA WITH LEWY BODIES, VASCULAR DEMENTIA WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2007-12-12 | — | — | EP | claimed |
| WO-2006103546-A2 | TREATMENT OF PARKINSON'S DISEASE, OBSTRUCTIVE SLEEP APNEA, DEMENTIA WITH LEWY BODIES, VASCULAR DEMENTIA WITH NON-IMIDAZOLE ALKYLAMINES HISTAMINE H3-RECEPTOR LIGANDS | BIOPROJET (FR) | 2006-10-05 | — | — | WO | claimed |