Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.63 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491723 | 0.94 | HRH3 (0.61) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL5484748 | 0.94 | HRH3 (0.61) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL491587 | 0.94 | HRH3 (0.61) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL491586 | 0.94 | HRH3 (0.61) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL12741679 | 0.94 | HRH3 (0.61) | SIGMAR1HRH3ALDH1A1 | |
| SCHEMBL491564 | 0.92 | SIGMAR1 (0.76) | SIGMAR1HRH3ACHEALDH1A1KDM4E | |
| SCHEMBL6052840 | 0.90 | HRH3 (0.64) | SIGMAR1HRH3ACHE | |
| Pitolisant SCHEMBL6052604 | 0.86 | HRH3 (0.61) | SIGMAR1HRH3 | |
| SCHEMBL17285907 | 0.83 | SIGMAR1 (0.74) | SIGMAR1HRH3ACHEALDH1A1KDM4E | |
| SCHEMBL6570233 | 0.82 | SIGMAR1 (0.62) | SIGMAR1HRH3ACHEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641461-A1 | COMBINATION PRODUCT COMPRISING AN ANTAGONIST OR INVERSE AGONIST OF HISTAMINE RECEPTOR H<SB>3</SB>AND AN ANTIPSYCHOTIC OR ANTIDEPRESSANT AGENT, AND USE THEREOF FOR THE PREPARATION OF A MEDICAMENT THAT PREVENTS THE ADVERSE EFFECTS OF PSYCHOTROPIC DRUGS | BIOPROJET (FR) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005000315-A1 | COMBINATION PRODUCT COMPRISING AN ANTAGONIST OR INVERSE AGONIST OF HISTAMINE RECEPTOR H3 AND AN ANTIPSYCHOTIC OR ANTIDEPRESSANT AGENT, AND USE THEREOF FOR THE PREPARATION OF A MEDICAMENT THAT PREVENTS THE ADVERSE EFFECTS OF PSYCHOTROPIC DRUGS | BIOPROJET (FR) | 2005-01-06 | — | — | WO | disclosed |