Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | MAP2K7 | O14733 | 5/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | CASP7 | P55210 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484991 | 1.00 | ENPP1 (0.44) | ENPP1MAP2K7CASP1CASP7HSD17B10 | |
| SCHEMBL5485646 | 0.87 | HRH4 (0.42) | ENPP1HSD17B10KDM4EALDH1A1HPGD | |
| SCHEMBL5485648 | 0.87 | HRH4 (0.42) | ENPP1HSD17B10KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL5485950 | 0.86 | HRH4 (0.41) | ENPP1HSD17B10KDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL5485955 | 0.86 | HRH4 (0.41) | ENPP1HSD17B10KDM4EALDH1A1GAA | |
| SCHEMBL5042661 | 0.82 | ALDH1A1 (0.43) | CASP1CASP7HSD17B10KDM4EALDH1A1 | |
| SCHEMBL5042666 | 0.82 | ALDH1A1 (0.43) | CASP1CASP7HSD17B10KDM4EALDH1A1 | |
| SCHEMBL5486348 | 0.82 | ENPP1 (0.43) | ENPP1PDE10APDE3BPDE3AMEN1 | |
| SCHEMBL5486343 | 0.82 | ENPP1 (0.43) | ENPP1PDE10APDE3BPDE3AMEN1 | |
| Hydrochloric Acid SCHEMBL5040355 | 0.81 | ALDH1A1 (0.42) | CASP1CASP7HSD17B10KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205309-B2 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-20040029901-A1 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029901-A1 | Quinazoline derivatives | GPR119, NQO2, CYP7A1 | ENPP1 4421/4885MAP2K7 4227/4885CASP1 1304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.