Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2898565 | 0.98 | PSEN1 (0.37) | ALDH1A1HPGDPSEN1PSEN2APH1B | |
| SCHEMBL2897435 | 0.84 | PSEN1 (0.41) | ALDH1A1HPGDPSEN1PSEN2APH1B | |
| SCHEMBL2896306 | 0.83 | PSEN1 (0.43) | ALDH1A1HPGDPSEN1PSEN2APH1B | |
| SCHEMBL4223764 | 0.81 | PSEN1 (0.37) | ALDH1A1HPGDPSEN1PSEN2APH1B | |
| SCHEMBL2889873 | 0.80 | CHRNB2 (0.44) | ALDH1A1HPGDPSEN1PSEN2APH1B | |
| SCHEMBL5482514 | 0.80 | PSEN1 (0.38) | ALDH1A1HPGDPSEN1PSEN2APH1B | |
| SCHEMBL2890137 | 0.79 | CHRNB2 (0.44) | ALDH1A1HPGDPSEN1PSEN2APH1B | |
| SCHEMBL2889558 | 0.70 | PSEN1 (0.38) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5485017 | 0.70 | NPC1 (0.38) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2893245 | 0.69 | ALDH1A1 (0.36) | ALDH1A1HPGDPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | claimed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259860-A1 | MGluR5 modulators V | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259860-A1 | MGluR5 modulators V | GRM5, GRIK5, GRM2 | ALDH1A1 4603/4885HPGD 2870/4885PSEN1 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.