Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5486783 | 0.84 | KMT2A (0.51) | KMT2AMEN1HSD17B10ALDH1A1MAPT | |
| SCHEMBL5026895 | 0.81 | NCF1 (0.51) | KMT2AMEN1ALDH1A1MAPTNPSR1 | |
| SCHEMBL5494681 | 0.81 | MEN1 (0.48) | KMT2AMEN1HRH4HSD17B10ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5493398 | 0.81 | MEN1 (0.50) | KMT2AMEN1HRH4HSD17B10ALDH1A1 | |
| SCHEMBL22911938 | 0.80 | MEN1 (0.57) | KMT2AMEN1HSD17B10KDM4EL3MBTL1 | |
| SCHEMBL5492423 | 0.78 | PIK3CA (0.56) | KMT2AMEN1HSD17B10ALDH1A1MAPT | |
| SCHEMBL5486974 | 0.77 | MAOB (0.47) | KMT2AMEN1HRH4KDM4EPRKDC | |
| SCHEMBL5412855 | 0.77 | CYP1A2 (0.53) | KMT2AMEN1HRH4ALDH1A1TSHR | |
| SCHEMBL5489231 | 0.74 | MEN1 (0.50) | KMT2AMEN1HSD17B10L3MBTL1MAPK1 | |
| SCHEMBL5485963 | 0.74 | MEN1 (0.50) | KMT2AMEN1HSD17B10L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205309-B2 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-20040029901-A1 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029901-A1 | Quinazoline derivatives | GPR119, NQO2, CYP7A1 | KMT2A 1664/4885MEN1 1326/4885HRH4 529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.