Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | LDHB | P07195 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3807642 | 0.89 | BID (0.47) | KMT2AMEN1NR1I2LMNACHRM2 | |
| SCHEMBL4351825 | 0.89 | BID (0.47) | KMT2AMEN1NR1I2LMNACHRM2 | |
| SCHEMBL28818542 | 0.88 | TSHR (0.47) | HTTLDHALDHBTSHRLTB4R | |
| SCHEMBL28193149 | 0.86 | PLA2G2A (0.49) | PLA2G2APLA2G10SIRT2TSHR | |
| SCHEMBL144959 | 0.84 | PARP1 (0.44) | KMT2AHTTTSHRMEN1NR1I2 | |
| SCHEMBL3352032 | 0.84 | PARP1 (0.41) | KMT2AHTTTSHRMEN1NR1I2 | |
| Oxalic Acid SCHEMBL27731733 | 0.83 | HMGB1 (0.38) | KMT2AHTTMEN1NR1I2LMNA | |
| Oxalic Acid SCHEMBL29264741 | 0.83 | PLA2G2A (0.46) | KMT2APLA2G2APLA2G10SIRT2TSHR | |
| Charcoal, Activated SCHEMBL9341326 | 0.83 | PARP1 (0.40) | KMT2AHTTTSHRMEN1NR1I2 | |
| SCHEMBL6314578 | 0.83 | PARP1 (0.40) | KMT2AHTTTSHRMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763509-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006002474-A1 | ALPHA-HELICAL MIMETICS | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2006-01-12 | — | — | WO | disclosed |