Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498410 | 0.92 | SLC6A2 (0.38) | SSTR5SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL5481894 | 0.91 | SSTR5 (0.38) | CETPSSTR5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5488867 | 0.91 | SSTR5 (0.38) | CETPSSTR5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5486981 | 0.90 | SSTR5 (0.37) | CETPSSTR5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5489237 | 0.87 | SSTR5 (0.39) | CETPSSTR5SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4594469 | 0.87 | SSTR5 (0.36) | SSTR5SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4866640 | 0.85 | MAPT (0.41) | SSTR5SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL5492474 | 0.84 | POLB (0.42) | SSTR5SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4594255 | 0.84 | SSTR5 (0.39) | SSTR5SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL5485960 | 0.83 | SSTR5 (0.38) | SSTR5SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |