Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 3/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5481894 | 0.88 | SSTR5 (0.38) | SSTR5TACR1CETPALDH1A1HTT | |
| SCHEMBL5486670 | 0.87 | CETP (0.39) | SSTR5TACR1CETPALDH1A1HTT | |
| SCHEMBL5488867 | 0.86 | SSTR5 (0.38) | SSTR5TACR1CETPALDH1A1HTT | |
| SCHEMBL5486981 | 0.86 | SSTR5 (0.37) | SSTR5TACR1CETPALDH1A1HTT | |
| SCHEMBL5485921 | 0.85 | PDE10A (0.36) | SSTR5F10METSLC6A2SLC6A4 | |
| SCHEMBL4866640 | 0.80 | MAPT (0.41) | SSTR5ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5485960 | 0.80 | SSTR5 (0.38) | SSTR5TACR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5492474 | 0.79 | POLB (0.42) | SSTR5ALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5498410 | 0.79 | SLC6A2 (0.38) | SSTR5TACR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5478920 | 0.78 | LMNA (0.40) | SSTR5MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |