Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | YAP1 | P46937 | 1/20 | 0.34 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.34 |
| ▸ | PAM | P19021 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1122555 | 0.66 | RELA (0.46) | LMNAALDH1A1TRPM8HTTSMN1; SMN2 | |
| SCHEMBL21800691 | 0.64 | USP2 (0.57) | LMNAALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL18864927 | 0.64 | ALDH1A1 (0.51) | LMNAALDH1A1HSP90AA1HTTMAPK1 | |
| SCHEMBL18864926 | 0.64 | ALDH1A1 (0.51) | LMNAALDH1A1HSP90AA1HTTMAPK1 | |
| SCHEMBL18172735 | 0.63 | KDM1A (0.56) | LMNAALDH1A1HTTSMN1; SMN2PAM | |
| SCHEMBL18172738 | 0.63 | KDM1A (0.56) | LMNAALDH1A1HTTSMN1; SMN2PAM | |
| SCHEMBL18173266 | 0.63 | KDM1A (0.56) | LMNAALDH1A1HTTSMN1; SMN2PAM | |
| SCHEMBL5051066 | 0.63 | ALDH1A1 (0.47) | LMNAALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL4016358 | 0.62 | GAA (0.51) | LMNAALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL21593710 | 0.61 | HTT (0.50) | LMNAALDH1A1HTTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007516982-A | — | — | 2007-06-28 | — | — | JP | claimed |
| EP-1694410-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | Japan Tobacco, Inc. (JP) | 2006-08-30 | — | — | EP | claimed |
| WO-2005058884-A2 | CYCLOPROPANE COMPOUNDS AND PHARMACEUTICAL USE THEREOF | JAPAN TOBACCO INC. (JP) | 2005-06-30 | — | — | WO | claimed |