SCHEMBL54869

SCHEMBL54869

CCOC(=O)C(Cl)C(C)=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.48
LMNA P02545 1/20 0.48
HSD17B10 Q99714 1/20 0.48
ALOX15 P16050 1/20 0.40
MGAM O43451 1/20 0.40
GAA P10253 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
SOAT1 P35610 1/20 0.40
TRPA1 O75762 1/20 0.37
GLO1 Q04760 1/20 0.37
CYP2C19 P33261 2/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
TSHR P16473 1/20 0.34
PIN1 Q13526 1/20 0.34
HPGD P15428 1/20 0.34
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10820963 0.98 ALDH1A1 (0.46) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL1444159 0.87 ALDH1A1 (0.50) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL26068495 0.81 ALDH1A1 (0.38) ALDH1A1LMNAHSD17B10GAACYP2C9
SCHEMBL9659057 0.81 ALDH1A1 (0.44) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL9939069 0.80 ALDH1A1 (0.43) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL1444162 0.80 ALDH1A1 (0.50) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL4330611 0.79 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL7940226 0.78 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL28694430 0.78 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL28000135 0.78 ALDH1A1 (0.42) ALDH1A1LMNAHSD17B10ALOX15MGAM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2842 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120192281-A Febuxostat Process for the preparation of intermediates 潍坊市海欣药业有限公司 2025-06-24 CN claimed
US-12281348-B2 Method for the continuous flow synthesis of (R)-4-halo-3-hydroxy-butyrate FUDAN UNIVERSITY (CN) 2025-04-22 US claimed
CN-119855815-A KRAS mutant protein inhibitor, and preparation method and application thereof 甘李药业股份有限公司 2025-04-18 CN claimed
CN-119552160-A Preparation method of apixaban 济南健丰化工有限公司 2025-03-04 CN claimed
CN-119529814-A Self-generated composite acid fracturing fluid without preparation and application thereof 中国石油天然气股份有限公司 2025-02-28 CN claimed
CN-119143651-A Method for preparing pyrrole and furan compounds from N-acetylglucosamine 南京工业大学 2024-12-17 CN claimed
CN-119074653-A Pearl dressing with sterilization, anti-inflammation and repair functions and preparation method thereof 湖北中珠制药有限公司 2024-12-06 CN claimed
CN-118994141-A Phenylthiazole derivative with anti-liver cancer and anti-inflammatory activities and preparation method and application thereof 河南科技大学 2024-11-22 CN claimed
CN-118994140-A Triazole derivative with antidepressant effect, and preparation method and application thereof 河南科技大学 2024-11-22 CN claimed
CN-118807509-A Modified polysulfone membrane and preparation method thereof 清华大学 2024-10-22 CN claimed
JP-2007500724-A 2007-01-18 JP claimed
EP-1651624-A2 PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLES Abbott Laboratories (US) 2006-05-03 EP claimed
CN-1721414-A Process for synthesizing 2-p-trifluoro toluene-4-methyl-5-thiazolyl ethyl formate UNIV ZHEJIANG (CN) 2006-01-18 CN claimed
US-20050075503-A1 Substituted thiazoles ABBVIE INC. 2005-04-07 US claimed
WO-2005012273-A2 PROCESS FOR THE PREPARATION OF SUBSTITUTED THIAZOLES ABBOTT LABORATORIES (US) 2005-02-10 WO claimed
US-20050027128-A1 Substituted thiazoles ABBOTT LABORATORIES 2005-02-03 US claimed
EP-0912467-B1 ASYMMETRIC HYDROGENATION METHOD OF A KETONIC COMPOUND AND DERIVATIVE RHODIA CHIMIE SA (FR) 2002-04-24 EP claimed
EP-0694564-B1 Latex polymers for pigmented coatings prepared in the presence of acetoacetate moiety NAT STARCH CHEM INVEST (US) 1999-03-24 EP claimed
EP-0694564-A1 Latex polymers for pigmented coatings prepared in the presence of acetoacetate moiety National Starch and Chemical Investment Holding Corporation (US) 1996-01-31 EP claimed
US-5455298-A Improved water resistance NATIONAL STARCH AND CHEMICAL INVESTMENT HOLDING CORPORATION (US) 1995-10-03 US claimed