SCHEMBL5487108

SCHEMBL5487108

NC=C1C(=O)NC(=O)NC1=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.47
KDM4E B2RXH2 4/20 0.47
OGT O15294 1/20 0.47
USP2 O75604 1/20 0.47
RECQL P46063 1/20 0.47
BLM P54132 1/20 0.47
METAP1 P53582 7/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
POLB P06746 1/20 0.39
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
CGAS Q8N884 1/20 0.35
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
XDH P47989 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10508164 0.77
SCHEMBL13615467 0.73 MAPT (0.45) MAPTKDM4EOGTUSP2RECQL
SCHEMBL123424 0.71
SCHEMBL12014049 0.71 METAP1 (0.45) MAPTKDM4EOGTUSP2RECQL
SCHEMBL20362831 0.69 MAPT (0.41) MAPTKDM4EOGTUSP2RECQL
SCHEMBL4428107 0.67 METAP1 (0.80) MAPTKDM4EMETAP1CA12CA1
SCHEMBL12013780 0.67 METAP1 (0.46) MAPTKDM4EOGTUSP2RECQL
SCHEMBL16543018 0.65 CGAS (0.70) MAPTKDM4EMETAP1CA12CA1
Alloxan SCHEMBL64547 0.65 MAPT (1.00) MAPTKDM4EOGTUSP2RECQL
SCHEMBL14033557 0.63 METAP1 (0.71) MAPTKDM4EMETAP1CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1236357-A Aminomethylene derivatives and ultraviolet absorber comprising the same CHEMIPRO KASEI KAISHA LTD (JP) 1999-11-24 CN claimed
EP-0950655-A1 AMINOMETHYLENE DERIVATIVES AND ULTRAVIOLET ABSORBER COMPRISING THE SAME CHEMIPRO KASEI KAISHA, LIMITED (JP) 1999-10-20 EP claimed
WO-2013129605-A1 FULLY ORGANIC DYE COMPOUND HAVING NON-PLANAR STRUCTURE FOR DYE-SENSITIZED PHOTOELECTRIC CONVERSION ELEMENTS, AND PHOTOELECTRIC CONVERSION ELEMENT USING SAME 関東天然瓦斯開発株式会社 (JP) 2013-09-06 WO disclosed
US-20070037838-A1 Herpes virus, Chlamydia virus, Influenza virus, HIV; TETS VIKTOR V 2007-02-15 US disclosed
EP-1669357-A1 SUBSTANCE WHICH EXHIBITS ANTIVIRAL AND ANTIBACTERIAL ACTIVITY AND IS BASED ON DERIVATIVES OF 2,8-DITHIOXO-1H-PYRANO 2,3D&cedi l;6,5-D DIPYRIMIDYNE AND 10-AZA-ANALOGUE THEREOF Tets, Viktor Veniaminovich (RU) 2006-06-14 EP disclosed
EP-1033369-B1 5H-PYRANO [2,3-d:6,5-d']DIPYRIMIDINE DERIVATIVES HAVING AN ANTIBACTERIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY NATURAL DRUG SCIENCES L L C (US) 2003-01-29 EP disclosed
US-6340755-B1 IMMUNOMMODULATORS, BACTERICIDES AND VIRICIDES NATURAL DRUG SCIENCES LLC 2002-01-22 US disclosed
EP-1033369-A1 5H-PYRANO [2,3-d:6,5-d']DIPYRIMIDINE DERIVATIVES HAVING AN ANTIBACTERIAL, ANTIVIRAL AND IMMUNO-MODULATING ACTIVITY Tets, Viktor Veniaminovich (RU) 2000-09-06 EP disclosed
US-6114546-A Aminomethylene derivatives and ultraviolet absorbent comprising thereof CHEMIPRO KASEI KAISHA, LIMITED (JP) 2000-09-05 US disclosed
CN-1236357-A Aminomethylene derivatives and ultraviolet absorber comprising the same CHEMIPRO KASEI KAISHA LTD (JP) 1999-11-24 CN disclosed
EP-0950655-A1 AMINOMETHYLENE DERIVATIVES AND ULTRAVIOLET ABSORBER COMPRISING THE SAME CHEMIPRO KASEI KAISHA, LIMITED (JP) 1999-10-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070037838-A1 Herpes virus, Chlamydia virus, Influenza virus, HIV; ADORA3, H1-5, H1-3 MAPT 4328/4885KDM4E 646/4885OGT 3882/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.