Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5498704 | 0.93 | TP53 (0.36) | TP53GAATSHRAGTR1CRHR1 | |
| SCHEMBL3271338 | 0.88 | TP53 (0.38) | TP53GAATSHRAGTR1CRHR1 | |
| SCHEMBL5492086 | 0.80 | TP53 (0.36) | TP53GAATSHRAGTR1CRHR1 | |
| SCHEMBL5488607 | 0.77 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL5488619 | 0.75 | CRHR1 (0.34) | TP53CRHR1P2RX7 | |
| SCHEMBL5488610 | 0.75 | CRHR1 (0.34) | TP53CRHR1 | |
| SCHEMBL5488616 | 0.74 | CRHR1 (0.33) | TSHRCRHR1ALDH1A1 | |
| SCHEMBL5494540 | 0.74 | SMN1; SMN2 (0.34) | TP53GAATSHRAGTR1CRHR1 | |
| SCHEMBL5105876 | 0.72 | TP53 (0.34) | TP53GAATSHRAGTR1CRHR1 | |
| SCHEMBL3271633 | 0.70 | CRHR1 (0.43) | TP53CRHR1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7279474-B2 | Substituted pyrrolo[2,3-d]pyrimidines as antagonists of the corticotropin releasing factor (CRF) | GLAXO GROUP LIMITED (GB) | 2007-10-09 | — | — | US | disclosed |
| US-20040176400-A1 | Fused pyrimidines as antagonists of the corticotropin releasing factor (crf) | GLAXO GROUP LIMITED (GB) | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176400-A1 | Fused pyrimidines as antagonists of the corticotropin releasing factor (crf) | CRH, CRHR1, CRHR2 | TP53 3584/4885GAA 2832/4885TSHR 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.