Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5495834 | 1.00 | KDM4E (0.59) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| Citric Acid SCHEMBL1672543 | 1.00 | KDM4E (0.59) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| Citric Acid SCHEMBL1672548 | 1.00 | KDM4E (0.59) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| Citric Acid SCHEMBL5495022 | 0.99 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| Citric Acid SCHEMBL5495033 | 0.99 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| SCHEMBL1672547 | 0.88 | KDM4E (0.60) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| SCHEMBL6137121 | 0.88 | KDM4E (0.60) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| SCHEMBL5495031 | 0.87 | KDM4E (0.58) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| SCHEMBL13348914 | 0.85 | KDM4E (0.65) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 | |
| SCHEMBL2062605 | 0.85 | KDM4E (0.65) | KDM4ESMN1; SMN2ALDH1A1TDP1ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453816-B1 | PHENOXY AMINE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2013-09-18 | — | — | EP | disclosed |
| US-7297794-B2 | Phenoxy amine compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2007-11-20 | — | — | US | disclosed |
| US-20050119502-A1 | Phenoxy amine compounds and compositions for delivering active agents | EMISPHERE TECHNOLOGIES, INC. (US) | 2005-06-02 | — | — | US | disclosed |
| EP-1453816-A4 | PHENOXY AMINE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2005-02-09 | — | — | EP | disclosed |
| EP-1453816-A2 | PHENOXY AMINE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | Emisphere Technologies, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003045306-A2 | PHENOXY AMINE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119502-A1 | Phenoxy amine compounds and compositions for delivering active agents | PNMT, SLC5A7, PHOSPHO1 | MEN1 1089/4885KDM4E 1807/4885SMN1; SMN2 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.