Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 7/20 | 0.40 |
| ▸ | CTSS | P25774 | 6/20 | 0.40 |
| ▸ | CTSB | P07858 | 4/20 | 0.40 |
| ▸ | CTSK | P43235 | 4/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188373 | 0.95 | CTSS (0.39) | CTSLCTSSCTSBCTSKKDM4E | |
| SCHEMBL4175687 | 0.93 | CNR1 (0.44) | CTSLCTSSCTSKRAB9AATM | |
| SCHEMBL4171002 | 0.91 | CTSL (0.49) | CTSLCTSSCTSBCTSKCCR1 | |
| SCHEMBL4183292 | 0.91 | USP30 (0.39) | CTSLCTSSCTSBCTSKKDM4E | |
| SCHEMBL4188282 | 0.88 | CTSS (0.54) | CTSLCTSSCTSBCTSKATM | |
| SCHEMBL4179274 | 0.88 | CNR1 (0.43) | CTSLCTSSCTSKRAB9AKMT2A | |
| SCHEMBL4188234 | 0.88 | CTSL (0.44) | CTSLCTSSCTSBCTSKCCR1 | |
| SCHEMBL4188233 | 0.88 | CTSL (0.44) | CTSLCTSSCTSBCTSKCCR1 | |
| SCHEMBL4185692 | 0.87 | CTSL (0.45) | CTSLCTSSCTSBCTSKRAB9A | |
| SCHEMBL4175983 | 0.87 | KDM4E (0.43) | KDM4ERAB9AATMHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869026-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-12-26 | — | — | EP | claimed |
| WO-2006105475-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-05 | — | — | WO | claimed |
| EP-1869026-A1 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105475-A1 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |