Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 6/20 | 0.37 |
| ▸ | PPARD | Q03181 | 6/20 | 0.37 |
| ▸ | PPARA | Q07869 | 6/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5483154 | 0.98 | SOAT1 (0.39) | SOAT1MEN1KMT2AFAAHTP53 | |
| SCHEMBL537434 | 0.91 | SOAT1 (0.36) | SOAT1MEN1KMT2AFAAHTP53 | |
| SCHEMBL30701400 | 0.83 | SOAT1 (0.57) | SOAT1MEN1KMT2AFAAHTP53 | |
| SCHEMBL30701337 | 0.83 | SOAT1 (0.57) | SOAT1MEN1KMT2AFAAHTP53 | |
| SCHEMBL5487841 | 0.82 | MEN1 (0.30) | SOAT1MEN1KMT2AFAAHTP53 | |
| SCHEMBL9634443 | 0.76 | FAAH (0.42) | MEN1KMT2AFAAHEPHX1CES2 | |
| SCHEMBL12296678 | 0.76 | NAAA (0.42) | MEN1KMT2AFAAHCYP1A2EPHX1 | |
| SCHEMBL10356297 | 0.74 | TSHR (0.53) | MEN1KMT2AEPHX1TSHRALDH1A1 | |
| SCHEMBL19119178 | 0.74 | TSHR (0.53) | MEN1KMT2AEPHX1TSHRALDH1A1 | |
| SCHEMBL10356295 | 0.74 | TSHR (0.53) | MEN1KMT2AEPHX1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737471-A2 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF LIPOPHILIC, SILICON-SUBSTITUTED, CYCLOOXYGENASE-2 SELECTIVE NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND DERIVATIVES | RND Pharmaceuticals (US) | 2007-01-03 | — | — | EP | claimed |
| WO-2005102358-A2 | SILICONE-SUBSTITUTED COX-2 SELECTIVE INHIBITORS | RND PHARMACEUTICALS (US) | 2005-11-03 | — | — | WO | claimed |