Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.42 |
| ▸ | CASP1 | P29466 | 5/20 | 0.42 |
| ▸ | CASP7 | P55210 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037487 | 0.84 | NCF1 (0.50) | MAOBKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL5036278 | 0.83 | NCF1 (0.52) | MAOBMEN1KMT2AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL5040498 | 0.82 | NCF1 (0.51) | MAOBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5491074 | 0.82 | MEN1 (0.57) | MEN1KMT2ANPY5RTP53ENPP1 | |
| SCHEMBL5486974 | 0.82 | MAOB (0.47) | MAOBMEN1KMT2AKDM4ENPY5R | |
| SCHEMBL5485312 | 0.81 | MEN1 (0.46) | MEN1KMT2ANPY5RMAPK1L3MBTL1 | |
| SCHEMBL5490756 | 0.81 | MEN1 (0.46) | MEN1KMT2AKDM4EALDH1A1NPY5R | |
| SCHEMBL5484958 | 0.80 | MEN1 (0.42) | MEN1KMT2AKDM4EALDH1A1NPY5R | |
| Hydrochloric Acid SCHEMBL5489384 | 0.76 | ENPP1 (0.53) | MAOBMEN1KMT2ANPY5RMAPK1 | |
| SCHEMBL5494681 | 0.76 | MEN1 (0.48) | MEN1KMT2AKDM4EALDH1A1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205309-B2 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-20040029901-A1 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029901-A1 | Quinazoline derivatives | GPR119, NQO2, CYP7A1 | MAOB 910/4885MEN1 1326/4885KMT2A 1664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.