Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.59 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6656679 | 0.87 | MAPK14 (0.67) | MAPK14HSPB1CYP2C9MAPK11 | |
| SCHEMBL6275051 | 0.84 | MAPK14 (0.54) | MAPK14HSPB1CYP2C9MAPK11 | |
| SCHEMBL28441973 | 0.82 | CA12 (0.67) | POLBHPGDHTTCA12CA1 | |
| SCHEMBL5632303 | 0.82 | MAPK14 (0.86) | MAPK14HSPB1CYP2C9MAPK11 | |
| SCHEMBL3001574 | 0.80 | CA12 (0.58) | POLBHPGDHTTCA12CA1 | |
| SCHEMBL13146376 | 0.80 | MAPK14 (0.79) | MAPK14HSPB1CYP2C9MAPK11 | |
| SCHEMBL16888470 | 0.79 | POLB (0.60) | MAPK14POLBHPGDHTTKDM4E | |
| SCHEMBL5101794 | 0.78 | MAPK14 (0.70) | MAPK14HSPB1CYP2C9MAPK11HPGD | |
| SCHEMBL4877481 | 0.77 | MAPK14 (0.43) | MAPK14HSPB1CYP2C9MAPK11POLB | |
| SCHEMBL6655486 | 0.77 | S1PR4 (0.67) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611085-B1 | BIPHENYL-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1435936-A1 | 5'-CARBAMOYL-1,1-BIPHENYL-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032972-A1 | 5’-CARBAMOYL-1,1-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |