Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 9/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.48 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522953 | 0.84 | S1PR4 (0.56) | S1PR4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6656679 | 0.78 | MAPK14 (0.67) | MAPK14 | |
| SCHEMBL5488332 | 0.77 | MAPK14 (0.59) | MAPK14 | |
| SCHEMBL5497228 | 0.76 | LCK (0.70) | S1PR4MAPK14 | |
| SCHEMBL13146376 | 0.76 | MAPK14 (0.79) | MAPK14 | |
| SCHEMBL6275051 | 0.75 | MAPK14 (0.54) | MAPK14EPHA3FRK | |
| SCHEMBL29854461 | 0.75 | MAPK14 (0.51) | MAPK14SUCNR1 | |
| SCHEMBL2950525 | 0.74 | MKNK1 (0.60) | — | |
| SCHEMBL10401801 | 0.74 | S1PR4 (0.60) | S1PR4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8226965 | 0.73 | MAPK14 (0.53) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435933-A1 | 5'-CARBAMOYL-2'-METHYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003032970-A1 | 5'-CARBAMOYL-2'-METHYL-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |