SCHEMBL5488837

SCHEMBL5488837

CCCCCc1cccc(C(=O)O)n1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.62
KDM4E B2RXH2 2/20 0.52
ALOX15 P16050 1/20 0.52
TSHR P16473 1/20 0.52
ACMSD Q8TDX5 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
CYP4F2 P78329 3/20 0.47
CYP4A11 Q02928 3/20 0.47
HCAR3 P49019 1/20 0.46
HCAR2 Q8TDS4 1/20 0.46
LMNA P02545 1/20 0.46
MRGPRX4 Q96LA9 1/20 0.46
BID P55957 3/20 0.45
MCL1 Q07820 3/20 0.45
BCL2L1 Q07817 2/20 0.45
BAK1 Q16611 2/20 0.45
KAT8 Q9H7Z6 2/20 0.45
PPARG P37231 1/20 0.45
PPARA Q07869 1/20 0.45
EP300 Q09472 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9096019 0.98 KCNH2 (0.66) KCNH2KDM4EALOX15TSHRACMSD
SCHEMBL2274224 0.97 KCNH2 (0.64) KCNH2KDM4EALOX15TSHRACMSD
SCHEMBL2932846 0.95 KCNH2 (0.55) KCNH2KDM4EALOX15TSHRACMSD
SCHEMBL5240216 0.88 KDM4E (0.57) KCNH2KDM4EALOX15TSHRACMSD
Bicarbonate SCHEMBL10966197 0.86 KCNH2 (0.78) KCNH2BIDMCL1BCL2L1BAK1
SCHEMBL15440738 0.85 KCNH2 (0.61) KCNH2BIDMCL1BCL2L1BAK1
SCHEMBL25537955 0.85 KDM4E (0.53) KCNH2KDM4EALOX15TSHRACMSD
Zinc Ion SCHEMBL9440280 0.84 KCNH2 (0.64) KCNH2BIDMCL1BCL2L1BAK1
SCHEMBL22096768 0.84 KCNH2 (0.64) KCNH2LMNABIDMCL1BCL2L1
SCHEMBL31591148 0.84 KDM4E (0.67) KCNH2KDM4EALOX15TSHRACMSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11976089-B2 Methods for the purification of L-glufosinate BASF SE (DE) 2024-05-07 US disclosed
US-11897909-B2 Methods for the purification of L-glufosinate BASF SE (DE) 2024-02-13 US disclosed
US-11897908-B2 Methods for the purification of L-glufosinate BASF SE (DE) 2024-02-13 US disclosed
US-20230331749-A1 METHODS FOR THE PURIFICATION OF L-GLUFOSINATE BASF SE (DE) 2023-10-19 US disclosed
US-20230250106-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2023-08-10 US disclosed
US-20230219985-A1 METHODS FOR THE PURIFICATION OF L-GLUFOSINATE BASF SE (DE) 2023-07-13 US disclosed
US-20230219984-A1 METHODS FOR THE PURIFICATION OF L-GLUFOSINATE BASF SE (DE) 2023-07-13 US disclosed
US-11634442-B2 Methods for the purification of L-glufosinate BASF SE (DE) 2023-04-25 US disclosed
US-20220177499-A1 METHODS FOR PRODUCING CRYSTALLINE L-GLUFOSINATE AMMONIUM MONOHYDRATE BASF SE (DE) 2022-06-09 US disclosed
EP-3956336-A1 METHODS FOR PRODUCING CRYSTALLINE L-GLUFOSINATE AMMONIUM MONOHYDRATE BASF SE (DE) 2022-02-23 EP disclosed
US-20140274715-A1 BROADLEAF CROP CONTROL WITH 6-ARYLPICOLINE CARBOXYLIC ACIDS, 2-ARYLPYRIMIDINE CARBOXYLIC ACIDS, OR SALTS OR ESTERS THEREOF DOW AGROSCIENCES LLC (US) 2014-09-18 US disclosed
US-8754229-B2 3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinates and their use as herbicides DOW AGROSCIENCES, LLC. (US) 2014-06-17 US disclosed
EP-2725903-A1 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6-(SUBSTITUTED)PICOLINATES AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2014-05-07 EP disclosed
WO-2013003740-A1 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6-(SUBSTITUTED)PICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2013-01-03 WO disclosed
US-20130005574-A1 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6-(SUBSTITUTED)PICOLINATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC 2013-01-03 US disclosed
US-20070249616-A1 Substituted 1-Benzyl-4-Substituted Piperazine Analogues NEUROGEN CORPORATION (US) 2007-10-25 US disclosed
US-7253168-B2 Substituted 1-benzyl-4-substituted piperazine analogues NEUROGEN CORPORATION (US) 2007-08-07 US disclosed
US-20060142301-A1 Substituted 1-benzyl-4-substituted piperazine analogues NEUROGEN CORPORATION 2006-06-29 US disclosed
US-20060009456-A1 Aryl-substituted piperazine derivatives NEUROGEN CORPORATION 2006-01-12 US disclosed
WO-2005110982-A2 SUBSTITUTED 1-BENZYL-4-SUBSTITUTED PIPERAZINE ANALOGUES NEUROGEN CORPORATION (US) 2005-11-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140274715-A1 BROADLEAF CROP CONTROL WITH 6-ARYLPICOLINE CARBOXYLIC ACIDS, 2-ARYLPYRIMIDINE CARBOXYLIC ACIDS, OR SALTS OR ESTERS THEREOF ABAT, NAT1, SLC7A5 KCNH2 1764/4885KDM4E 1643/4885ALOX15 2785/4885
US-20130005574-A1 3-ALKOXY, THIOALKYL AND AMINO-4-AMINO-6-(SUBSTITUTED)PICOLINATES AND THEIR USE AS HERBICIDES DDT, AADAC, AADAT KCNH2 2601/4885KDM4E 1083/4885ALOX15 2247/4885
US-20230250106-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 KCNH2 2622/4885KDM4E 3761/4885ALOX15 3036/4885
US-20070249616-A1 Substituted 1-Benzyl-4-Substituted Piperazine Analogues MCHR1, MCHR2, PRLHR KCNH2 2579/4885KDM4E 1136/4885ALOX15 3306/4885
US-20060009456-A1 Aryl-substituted piperazine derivatives MCHR1, MCHR2, PRLHR KCNH2 2807/4885KDM4E 1610/4885ALOX15 3539/4885
US-20060142301-A1 Substituted 1-benzyl-4-substituted piperazine analogues MCHR1, MCHR2, PRLHR KCNH2 2579/4885KDM4E 1136/4885ALOX15 3306/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.