Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16888352 | 0.98 | SOAT1 (0.41) | LTA4HSOAT1CYP3A4SMYD2HTT | |
| SCHEMBL18724647 | 0.98 | SOAT1 (0.41) | LTA4HSOAT1CYP3A4SMYD2HTT | |
| SCHEMBL13284463 | 0.98 | SOAT1 (0.41) | LTA4HSOAT1CYP3A4SMYD2HTT | |
| SCHEMBL15426891 | 0.98 | SOAT1 (0.41) | LTA4HSOAT1CYP3A4SMYD2HTT | |
| SCHEMBL6276817 | 0.97 | SOAT1 (0.40) | LTA4HSOAT1CYP3A4SMYD2HTT | |
| SCHEMBL702653 | 0.95 | LTA4H (0.42) | LTA4HCYP3A4SMYD2HTTSMN1; SMN2 | |
| SCHEMBL15686013 | 0.91 | LTA4H (0.36) | LTA4HSOAT1CYP3A4SMYD2HTT | |
| SCHEMBL15686035 | 0.90 | SOAT1 (0.36) | LTA4HSOAT1CYP3A4TSHRALDH1A1 | |
| SCHEMBL4341940 | 0.90 | PPARG (0.41) | SOAT1FAAHCNR1 | |
| SCHEMBL15686034 | 0.90 | SOAT1 (0.36) | LTA4HSOAT1CYP3A4TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3211085-A1 | ADENO-ASSOCIATED VIRUS (AAV) CLADES, SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREFOR | The Trustees of The University of Pennsylvania (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-2292780-B1 | Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof | UNIV PENNSYLVANIA (US) | 2017-08-23 | — | — | EP | disclosed |
| WO-2017123634-A1 | FORMULATIONS AND METHODS FOR TREATING ULCERATIVE COLITIS | SYNERGY PHARMACEUTICALS, INC. (US) | 2017-07-20 | — | — | WO | disclosed |
| US-20150284470-A1 | CRYSTAL STRUCTURES OF HETERODIMERIC Fc DOMAINS | ZYMEWORKS INC. (CA) | 2015-10-08 | — | — | US | disclosed |
| WO-2014088897-A1 | PALLADIUM-CATALYZED DECARBONYLATION OF FATTY ACID ANHYDRIDES FOR THE PRODUCTION OF LINEAR ALPHA OLEFINS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-06-12 | — | — | WO | disclosed |
| CN-103764621-A | Epoxyeicosatrienoic acid analogs and methods of making and using the same | MCW RES FOUND INC | 2014-04-30 | — | — | CN | disclosed |
| EP-2694470-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | M.C.W. Research Foundation, Inc. (US) | 2014-02-12 | — | — | EP | disclosed |
| WO-2012138706-A1 | EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME | MCW RESEARCH FOUNDATION, INC. (US) | 2012-10-11 | — | — | WO | disclosed |
| EP-2392580-A1 | 2'-fluoronucleosides | Emory University (US) | 2011-12-07 | — | — | EP | disclosed |
| US-20090012139-A1 | AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2009-01-08 | — | — | US | disclosed |
| EP-1754710-A2 | 2'-Fluoroncucleosides | Emory University (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1058686-B1 | 2'-FLUORONUCLEOSIDES | UNIV EMORY (US) | 2006-11-02 | — | — | EP | disclosed |
| EP-1058686-A1 | 2'-FLUORONUCLEOSIDES | EMORY UNIVERSITY (US) | 2000-12-13 | — | — | EP | disclosed |
| WO-1999043691-A1 | 2'-FLUORONUCLEOSIDES | EMORY UNIVERSITY (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090012139-A1 | AMINO-5-[4-(DIFLUOROMETHOXY) PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS FOR THE INHIBITION OF BETA-SECRETASE | BACE1, BACE2, APP | LTA4H 2530/4885SOAT1 3018/4885CYP3A4 3960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.