Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395812 | 0.84 | SMN1; SMN2 (0.53) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL397184 | 0.77 | KDM4E (0.53) | RXFP1ALDH1A1MAPTKDM4ELMNA | |
| SCHEMBL14472396 | 0.74 | KDM4E (0.63) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL10257067 | 0.73 | CYP2D6 (0.52) | MAPTLMNAKMT2AMEN1TDP1 | |
| SCHEMBL11075264 | 0.70 | KDM4E (0.61) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL6300719 | 0.70 | ALDH1A1 (0.67) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL29860485 | 0.70 | SMN1; SMN2 (0.58) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL19846945 | 0.70 | KDM4E (0.58) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL27659536 | 0.70 | SMN1; SMN2 (0.58) | ALDH1A1MAPTKDM4ELMNAKMT2A | |
| SCHEMBL538291 | 0.70 | SMN1; SMN2 (0.69) | ALDH1A1MAPTKDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502913-A2 | Modulators of ATP-binding cassette transporters | Vertex Pharmaceuticals Incorporated (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-1773816-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | Vertex Pharmaceuticals Incorporated (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006002421-A2 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-01-05 | — | — | WO | disclosed |