Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Frovatriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B known ✓ | P28222 | 3/20 | 0.98 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.88 |
| ▸ | HTR1A | P08908 | 3/20 | 0.98 |
| ▸ | DRD2 | P14416 | 2/20 | 0.98 |
| ▸ | DRD4 | P21917 | 1/20 | 0.98 |
| ▸ | HTR1E | P28566 | 1/20 | 0.98 |
| ▸ | HTR7 | P34969 | 1/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.98 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Frovatriptan SCHEMBL672784 | 1.00 | HTR1B (0.98) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Frovatriptan SCHEMBL2321442 | 0.99 | HTR1B (1.00) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Frovatriptan SCHEMBL2456983 | 0.94 | HTR1B (1.00) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Frovatriptan SCHEMBL29360449 | 0.94 | HTR1B (1.00) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Frovatriptan SCHEMBL34410 | 0.94 | HTR1B (1.00) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Frovatriptan SCHEMBL16365906 | 0.94 | HTR1B (1.00) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Frovatriptan SCHEMBL3474278 | 0.92 | HTR1B (0.98) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Succinic Acid SCHEMBL7109541 | 0.89 | HTR1B (0.78) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Succinic Acid SCHEMBL7748928 | 0.89 | HTR1B (0.78) | HTR1BHTR1ADRD2DRD4HTR1E | |
| Succinic Acid SCHEMBL3801747 | 0.88 | HTR1B (0.80) | HTR1BHTR1ADRD2DRD4HTR1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070299123-A1 | Amorphous frovatriptan succinate and process for the preparation thereof | GLENMARK PHARMACEUTICALS LIMITED (IN) | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299123-A1 | Amorphous frovatriptan succinate and process for the preparation thereof | SI, SUCNR1, SDHA | HTR1B 2954/4885HTR1D 1846/4885HTR1A 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.