Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.57 |
| ▸ | BCHE | P06276 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.57 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.57 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.57 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.57 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.57 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.57 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.57 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.57 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | FABP1 | P07148 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31139194 | 1.00 | ACHE (0.57) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL31139198 | 0.97 | BCHE (0.57) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL31139216 | 0.90 | ACHE (0.56) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL28449689 | 0.90 | ACHE (0.56) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL31139207 | 0.87 | ACHE (0.56) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL5487150 | 0.87 | ACHE (0.55) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL28422819 | 0.86 | ACHE (0.55) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL4879677 | 0.84 | ACHE (0.59) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL9633896 | 0.83 | ALDH1A1 (0.56) | ACHEBCHEALDH1A1TSHRHSD17B10 | |
| SCHEMBL22470553 | 0.82 | BCHE (0.50) | ACHEBCHEALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111592530-B | Acldoxime-containing tacrine derivative selective butyrylcholinesterase inhibitor and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-111592530-A | Acldoxime-containing tacrine derivative selective butyrylcholinesterase inhibitor and preparation method and application thereof | 山东大学 | 2020-08-28 | — | — | CN | disclosed |
| CN-103864759-A | Tacrine- nicotinic acid conjugate, preparation method and medical application thereof | UNIV CHINA PHARMA | 2014-06-18 | — | — | CN | disclosed |
| CN-101146800-A | Organic compounds for the treatment of alzheimer's disease, their use and process for their preparation | UNIV BOLOGNA ALMA MATER (IT) | 2008-03-19 | — | — | CN | disclosed |
| US-20070299093-A1 | Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation | Alma Mater Studiorum-Universitá Di Bologna (IT) | 2007-12-27 | — | — | US | disclosed |
| US-7307083-B2 | Tetrahydro-acridine and dithiolane derivatives | ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNA (IT) | 2007-12-11 | — | — | US | disclosed |
| EP-1853594-A2 | ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, THEIR USE AND METHOD OF PREPARATION | Alma Mater Studiorum -Universita' di Bologna (IT) | 2007-11-14 | — | — | EP | disclosed |
| US-20070219241-A1 | Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation | ALMA MATER STUDIORUM-UNIVERSITA'DI BOLOGNA (IT) | 2007-09-20 | — | — | US | disclosed |
| WO-2006080043-A2 | ORGANIC COMPOUNDS USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, THEIR USE AND METHOD OF PREPARATION | ALMA MATER STUDIORUM- UNIVERSITA' DI BOLOGNA (IT) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219241-A1 | Organic Compounds Useful For The Treatment Of Alzheimer's Disease, Their Use And Method Of Preparation | OTC, PSEN2, PSEN1 | ACHE 5/4885BCHE 7/4885ALDH1A1 159/4885 |
| US-20070299093-A1 | Organic Compounds Useful for the Treatment of Alzheimer's Disease, Their Use and Method of Preparation | OTC, PSEN2, PSEN1 | ACHE 5/4885BCHE 7/4885ALDH1A1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.